As a medical device intended for direct contact with human tissues or blood, the performance requirements for medical adhesives must strike a balance between efficacy, safety, and clinical applicability. Their core performance requirements can be summarized as follows:
Rapid Curing: Capable of rapid polymerization and curing-achieving immediate adhesion-upon contact with blood or tissue fluids under standard temperature and pressure conditions.
Robust Adhesion Strength and Durability: Forms a strong, long-lasting bond with tissues, ensuring stable wound closure.
Superior Biocompatibility: Non-toxic, non-sensitizing, and non-carcinogenic; meets biocompatibility testing standards such as ISO 10993-5.
Resistance to Body Fluid Degradation: Maintains structural and functional stability within physiological media, including blood, tissue fluids, bile, and gastric acid.
Ease of Use: Features application methods-such as easy spreading, spraying, or endoscopic delivery-that are well-suited to various clinical scenarios.
On-Demand Biodegradability: When used in vivo, it should safely degrade after fulfilling its intended function, thereby preventing long-term retention of foreign bodies.
Elasticity and Toughness: Upon curing, the adhesive film must possess sufficient flexibility to accommodate body movements and minimize tension-related tissue injury.
Sealing and Barrier Function: Forms a dense film layer that acts as a barrier against bacterial invasion, thereby reducing the risk of infection.
