Medical adhesives typically refer to medical glues used for the bonding, sealing, and protection of skin or wounds; their core principles are based on rapid polymerization and curing, as well as the properties of biocompatible materials.
Main Components: Primarily consist of α-cyanoacrylate compounds (e.g., n-butyl α-cyanoacrylate).
Curing Mechanism: Upon contact with anions (such as OH⁻) present in wound blood or tissue fluids, a rapid anionic polymerization reaction occurs, forming a mesh-like polymer film that adheres tightly to the wound surface.
Adhesive Film Structure: Under electron microscopy, it presents as a mesh-like structure with a diameter of approximately 2–3 μm, capable of effectively interlocking within tissue interstices to achieve physical sealing.
Medical adhesive closure is a technique employed in the minimally invasive treatment of vascular diseases, specifically finding application in the management of lower-extremity varicose veins. This technique achieves vascular occlusion through ultrasound-guided injection, featuring a relatively simplified procedural protocol. In clinical practice, this method is characterized by its ability to avoid thermal injury and its low recurrence rate; treatment is typically administered using local anesthesia and a minimally invasive percutaneous approach.
